Atpenin A5 CAS 119509-24-9

Product Description:

Product Name: Atpenin A5 CAS NO: 119509-24-9

Synonyms:

(2S,4S,5R)-1-(2,4-Dihydroxy-5,6-dimethoxy-3-pyridinyl)-2,4-dimethyl-5,6-dichloro-1-hexanone;

3-(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone;

Atpenin A5 (Synthetic);

Chemical Physical Properties:

Appearance: White to off-white powder

Assay : Greater than or equal to 99.0 percent

Density: 1.31g/cm3

Boiling Point: 532.6 degree at 760 mmHg

Flash Point: 275.9 degree

Refractive Index: 1.534

Vapor Pressure: 1.45E-13mmHg at 25 degree

Enantioselective total synthesis of atpenin A5, a potent mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor, has been achieved by a convergent approach through a coupling reaction between 5-iodo-2,3,4,6-tetraalkoxypyridine and a side-chain aldehyde. The two key segments were synthesized through ortho-metalation/boronation with (MeO)3B/oxidation with mCPBA, ortho-iodination, halogen dance reaction, Sharpless epoxidation and regioselective epoxide-opening reaction.

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