MonoMethyl Auristatin E(MMAE) CAS 474645-27-7

Product Description:

Product Name: MonoMethyl auristatin E(MMAE) CAS NO: 474645-27-7

Synonyms:

HM-297C-22;

MonoMethyl auristatin E;MMAE;

N-Methyl-L-valyl-N-(1S,2R)-4-(2S)-2-(1R,2R)-3-(1R,2S)-2-hydroxy-1-methyl-2-phenylethylamino-1-methoxy-2-methyl-3-oxopropyl-1-pyrrolidinyl-2-methoxy-1-(1S)-1-methylpropyl-4-oxobutyl-N-methyl-L-valinamide Monomethyl;

Chemical Physical Properties:

Appearance: Solid powder

Assay : Greater than or equal to 99.0 percent

Boiling Point: 873.5±65.0 degree (Predicted)

Density: 1.088±0.06 g/cm3(Predicted)

Pka: 13.66±0.20(Predicted)

Vapour Pressure: {{0}}.0±0.3 mmHg at 25 degree

Index of Refraction: 1.519

MMAE is an effective and synthetic cytotoxic analog of Dolastatin 10 which is a potent antimitotic polypeptide isolated from a marine animal.

Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization. Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity. MMAE is typically coupled to the antibody via a protease-cleavable linker, allowing separation of the drug from the antibody following intracellular localization.

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